Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort
June 30, 2021
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Rheumatoid arthritis (RA) is likely one of the advanced ailments with the involvement of the genetic in addition to environmental elements in its onset and severity. Completely different genome-wide affiliation and candidate gene research have proven the function of a number of genetic variants in a number of loci/genes with ethnical and geographical variations. This examine was designed to detect the affiliation of a single-nucleotide polymorphism (SNP) rs10865035 within the AFF3 gene with the genetic background of rheumatoid arthritis (RA) within the Pakistani cohort.
A complete of 703 people, together with 409 RA sufferers and 294 wholesome controls, have been genotyped utilizing TaqMan assay and Tri primer ARMS-PCR (amplification-refractory mutation system-polymerase chain response) strategies. The affiliation of rs10865035 with the RA was statistically decided utilizing totally different fashions.
Curiously, apart from the homozygous recessive mannequin (G/G vs. A/G + A/A) (OR = 1.693(1.06-2.648); P = 0.025), all different fashions, which included the codominant (χ 2 = 5.169; P = 0.075), homozygous dominant (A/A vs. G/G + A/G) (OR = 0.867 (0.636-1.187); P = 0.41), heterozygous (A/G vs. A/A + GG) (OR = 0.491 (0.667-1.215); P = 0.49), and additive mannequin (OR = 0.826 (0.665-1.027); P = 0.08) confirmed insignificant distribution of the genotypes among the many instances and controls. These findings counsel that the AFF3 gene (rs10865035) has no vital function within the onset of RA within the Pakistani inhabitants.
Determinants of first-line organic remedy in sufferers with rheumatoid arthritis: Outcomes from an observational examine
Pointers for the remedy of rheumatoid arthritis (RA) suggest using typical artificial illness modifying anti-rheumatic medicine (cs-DMARDs) on the onset of the illness and solely within the case of therapeutic failure, the addition of a organic drug (b-DMARD) is usually recommended.The examine aimed to judge determinants for first-line organic remedy in sufferers with RA in scientific observe.
A cohort of sufferers with RA, resident in Lazio, a central Italian Area, the place Rome is situated, and with a minimum of one illness modifying anti-rheumatic medicine (DMARD) prescription between 2010 and 2016 was chosen utilizing well being info methods linkable with one another by a person distinctive nameless identifier. Particularly RA cohort was outlined retrieving all sufferers with a minimum of a RA illness code in regional knowledge claims (hospital discharge, exemption code, emergency division entry, or therapeutic plan).
Solely new customers have been included and the first-line remedy was recognized: cs-DMARD or b-DMARD.Descriptive evaluation in accordance with kind of DMARD remedy was carried out. By means of multivariate logistic regression fashions (odds ratio [OR]; confidence interval [CI95%]) determinants of remedy akin to age, comorbidity, and comedication have been investigated.
Lastly, switching throughout the first 12 months of remedy from cs-DAMARDs to b-DMARDs was analyzed.DMARD-new customers with RA have been 5641; 7.1% of them with b-DMARD as first-line remedy. Contemplating the 12 months of dishing out, this proportion ranged from 4.9% (2011) to eight.2% (2015). Amongst cs-DMARD essentially the most prescribed energetic agent was methotrexate (59.3%), whereas amongst b-DMARD it was etarnecept (37.0%), adopted by adalimumab (21.2%).
The typical age of the cohort was 54 years with 77% of girls. Determinants of first-line b-DMARD use have been: age (OR<30vs>65 = 3.7; 2.6-5.2, OR[30-45)vs>65 = 1.7; 1.2-2.4, OR[45-55)vs>65 = 1.6; 1.1-2.4, OR[55-65)vs>65 = 1.2; 0.8-1.7), cancers (OR = 2.3; 1.3-4.2), cardio-cerebrovascular disease (OR = 1.4; 1.0-1.9), use of non-steroidal anti-inflammatory drugs (NSAIDs) (OR = 0.6; 0.4-0.7) and corticosteroids (OR = 0.6; 0.5-0.7) in the 6 months preceding diagnosis.In the first year of treatment, we observed a percentage of switch from cs-DMARDs to b-DMARDs of 7.9%.In clinical practice, about 7% of patients with RA are prescribed with a b-DMARD as first-line treatment. This therapeutic option, even if not supported by guide lines, is mostly link to younger age and clinical profile of the patients.
Penta-acetyl Geniposide Suppresses Migration, Invasion, and Irritation of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes Involving Wnt/β-Catenin Signaling Pathway
We beforehand reported that penta-acetyl geniposide ((Ac)5GP, an energetic by-product of geniposide) confirmed anti-arthritic impact on adjuvant-induced arthritis (AIA) rats by selling the apoptosis of AIA fibroblast-like synoviocyte (FLS). This examine aimed to exhibit the consequences of (Ac)5GP on migration, invasion, and irritation of TNF-α-stimulated rheumatoid arthritis (RA) FLS (MH7A cell) and to discover the concerned mechanisms.
MTT assay was used to find out the utilized non-cytotoxic doses of (Ac)5GP (12.5, 25, 50 μM) in vitro. Outcomes of wound-healing, transwell, and phalloidin staining assays indicated that (Ac)5GP lowered the migration, invasion, and F-actin cytoskeletal reorganization of TNF-α-stimulated MH7A. Outcomes of ELISA and western blot assays confirmed that (Ac)5GP lowered TNF-α-induced manufacturing of pro-inflammatory cytokines (like IL-1β, IL-6, IL-8) and matrix metalloproteinases (MMPs, akin to MMP-2 and MMP-9).
Furthermore, (Ac)5GP inhibited TNF-α-induced activation of Wnt/β-catenin pathway, evidenced by decreasing the protein ranges of Wnt1, p-GSK-3β (Ser9), and β-catenin and stopping β-catenin nuclear translocation. Importantly, the mixture of XAV939 (an inhibitor of Wnt/β-catenin) promoted the actions of (Ac)5GP on TNF-α-induced migration, invasion, and irritation, additional revealing the involvement of Wnt/β-catenin pathway underlying the therapeutic results of (Ac)5GP on TNF-α-stimulated MH7A.
Alpha Fluor™ 488 acid [equivalent to Alexa Fluor™ 488 acid] |
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Anti-Hu CD16 Alexa Fluor® 488 |
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Goat anti Mouse IgG1 (Alexa Fluor 488) |
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Description: Goat anti Mouse IgG1 secondary antibody (Alexa Fluor 488) |
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Anti-Hu CD72 Alexa Fluor® 488 |
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Anti-Bov CD9 Alexa Fluor® 488 |
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AF488 Phalloidin [equivalent to Alexa Fluor® 488 phalloidin] |
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XFD488 aldehyde *Same Structure to Alexa Fluor™ 488 aldehyde* |
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Anti-Hu CD3 zeta (pY153) Alexa Fluor® 488 |
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Anti-Hu CD3 zeta (pY72) Alexa Fluor® 488 |
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Anti-Hu CD3 zeta (pY142) Alexa Fluor® 488 |
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Description: Mouse Monoclonal Langerin (human) Antibody (DCGM4/122D5) (Alexa Fluor® 488). Validated in IHC and tested in Human. |
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Alpha Fluor™ 488 NHS Ester |
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Streptavidin-Alexa488 (Alexas fluor 488) conjugate |
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SAM FCM (Alexa Fluor 647) |
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Rabbit Anti-Rat IgG (H+L)-Alexa 488 Fluor conjugate (adsorbed with human IgG) |
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| 50336 | Alpha Diagnostics | 0.5 ml | EUR 270 |
XFD488 Anti-human CD305 Antibody *NKTA255, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD305 Antibody *NKTA255, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD314 Antibody *1D11, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD314 Antibody *1D11, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD318 Antibody *CUB1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD318 Antibody *CUB1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD324 Antibody *67A4, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 13240150 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD324 Antibody *67A4, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD334 Antibody *4FR6D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD334 Antibody *4FR6D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD340 Antibody *24D2, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 13400150 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD340 Antibody *24D2, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *HIT3b, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *HIT3b, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *UCHT1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *UCHT1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *SK7, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD3 Antibody *SK7, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD4 Antibody *HIT4a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD4 Antibody *HIT4a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10040151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD4 Antibody *SK3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD4 Antibody *SK3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD5 Antibody *HISM2, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD5 Antibody *HISM2, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10050151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD5 Antibody *L17F12, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD5 Antibody *L17F12, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10051151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD5 Antibody *UCHT2, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD5 Antibody *UCHT2, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD6 Antibody *HI210, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD6 Antibody *HI210, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD7 Antibody *HIT7, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD7 Antibody *HIT7, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD8 Antibody *HIT8a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD8 Antibody *HIT8a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD8 Antibody *SK1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD8 Antibody *SK1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD9 Antibody *HI9a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD9 Antibody *HI9a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD10 Antibody *HI10a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD10 Antibody *HI10a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11a Antibody *HI111, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11a Antibody *HI111, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10110151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD11b Antibody *HI11b, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11b Antibody *HI11b, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10111151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD11b Antibody *ICRF44, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11b Antibody *ICRF44, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11c Antibody *3.9, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD11c Antibody *3.9, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD13 Antibody *WM15, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10130150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD13 Antibody *WM15, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10130151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD14 Antibody *61D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD14 Antibody *61D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD15 Antibody *HI98, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD15 Antibody *HI98, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD16 Antibody *HI16a, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD16 Antibody *HI16a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10160151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD16 Antibody *3G8, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD16 Antibody *3G8, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD18 Antibody *HI18a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10180150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD18 Antibody *HI18a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10180151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD19 Antibody *HI19a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10190150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD19 Antibody *HI19a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10190151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD19 Antibody *SJ25C1, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD19 Antibody *SJ25C1, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10191151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD19 Antibody *HIB19, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10192150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD19 Antibody *HIB19, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10192151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD19 Antibody *4G7, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10193150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD19 Antibody *4G7, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10193151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-mouse CD19 Antibody *1D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10194140 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-mouse CD19 Antibody *1D3, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD20 Antibody *HI20a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10201150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD20 Antibody *HI20a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10201151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD21 Antibody *HI21a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10210150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD21 Antibody *HI21a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10210151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD22 Antibody *HIB22, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10220150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD22 Antibody *HIB22, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10220151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD24 Antibody *HI45, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10240150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD24 Antibody *HI45, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10240151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD25 Antibody *HI25a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10250150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD25 Antibody *HI25a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10250151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD25 Antibody *7G7B6, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10251150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD25 Antibody *7G7B6, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10251151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD27 Antibody *LT27, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10270150 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD27 Antibody *LT27, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10270151 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD27 Antibody *O323, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10271140 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD27 Antibody *O323, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10271141 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD1 Antibody *HI149, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10010140 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD1 Antibody *HI149, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD1 Antibody *SN13, XFD488 Same Structure to Alexa Fluor™ 488* |
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XFD488 Anti-human CD1 Antibody *SN13, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10012141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD1 Antibody *L161, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10013140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD1 Antibody *L161, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10013141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD2 Antibody *HIT11, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10020150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD2 Antibody *HIT11, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10020151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD3 Antibody *HIT3a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10030150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD3 Antibody *HIT3a, XFD488 Same Structure to Alexa Fluor™ 488* |
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| 10030151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD109 Antibody *W7C5, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11090140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD109 Antibody *W7C5, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11090141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD111 Antibody *R1.302, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11110140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD111 Antibody *R1.302, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11110141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD112 Antibody *R2.525, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11120140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD112 Antibody *R2.525, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11120141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD114 Antibody *LMM741, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11140140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD114 Antibody *LMM741, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11140141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD116 Antibody *4H1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11160140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD116 Antibody *4H1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11160141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD117 Antibody *104D2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11170150 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD117 Antibody *104D2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11170151 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD120a Antibody *H398, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11200140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD120a Antibody *H398, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11200141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD122 Antibody *TU27, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11220140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD122 Antibody *TU27, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11220141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD123 Antibody *6H6, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11230150 | AAT Bioquest | 100 tests | EUR 157 |
XFD488 Anti-human CD123 Antibody *6H6, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11230151 | AAT Bioquest | 500 tests | EUR 484 |
XFD488 Anti-human CD123 Antibody *12H7, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11231140 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD123 Antibody *12H7, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11231141 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD133 Antibody *293C3, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11330140 | AAT Bioquest | 100 tests | EUR 607 |
XFD488 Anti-human CD133 Antibody *293C3, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11330141 | AAT Bioquest | 500 tests | EUR 2280 |
XFD488 Anti-human CD135 Antibody *BV10A4, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11350140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD135 Antibody *BV10A4, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11350141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD138 Antibody *MI15, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11380150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD138 Antibody *MI15, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11380151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD140a Antibody *16A1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11400140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD140a Antibody *16A1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11400141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD140b Antibody *18A2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11401140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD140b Antibody *18A2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11401141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD152 Antibody *BN13, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11520150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD152 Antibody *BN13, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11520151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD160 Antibody *BY55, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11600140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD160 Antibody *BY55, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11600141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD162 Antibody *TC2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11620140 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD162 Antibody *TC2, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 11620141 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD58 Antibody *HI58a, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10580150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD58 Antibody *HI58a, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10580151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD62 Antibody *HI62E, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10620150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD62 Antibody *HI62E, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10620151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD62l Antibody *HI62L, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10621150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD62l Antibody *HI62L, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10621151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD62p Antibody *HI62P, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10622150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD62p Antibody *HI62P, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10622151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD64 Antibody *10.1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10640150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD64 Antibody *10.1, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10640151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD69 Antibody *FN50, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10690150 | AAT Bioquest | 100 tests | EUR 547 |
XFD488 Anti-human CD69 Antibody *FN50, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10690151 | AAT Bioquest | 500 tests | EUR 2051 |
XFD488 Anti-human CD71 Antibody *HI160, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10710150 | AAT Bioquest | 100 tests | EUR 245 |
XFD488 Anti-human CD71 Antibody *HI160, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10710151 | AAT Bioquest | 500 tests | EUR 918 |
XFD488 Anti-human CD71 Antibody *HI166, XFD488 Same Structure to Alexa Fluor™ 488* |
|||
| 10711150 | AAT Bioquest | 100 tests | EUR 245 |
In vivo, (Ac)5GP relieved the development and severity of rat collagen-induced arthritis, associated to decreasing the degrees of IL-1β, IL-6, IL-8, MMP-2, and MMP-9 in addition to inhibiting Wnt/β-catenin pathway in synovial tissues. Collectively, (Ac)5GP may suppress TNF-α-induced migration, invasion, and irritation in RA FLS involving Wnt/β-catenin pathway and (Ac)5GP could be as a candidate agent for RA remedy.RatRat