Development and validation of a nomogram for predicting stroke risk in rheumatoid arthritis patients
We developed and validated a nomogram to foretell the danger of stroke in sufferers with rheumatoid arthritis (RA) in northern China. Out of six machine studying algorithms studied to enhance diagnostic and prognostic accuracy of the prediction mannequin, the logistic regression algorithm confirmed excessive efficiency by way of calibration and resolution curve evaluation.
The nomogram included stratifications of intercourse, age, systolic blood stress, C-reactive protein, erythrocyte sedimentation charge, complete ldl cholesterol, and low-density lipoprotein ldl cholesterol together with the historical past of conventional danger elements similar to hypertensive, diabetes, atrial fibrillation, and coronary coronary heart illness.
The nomogram exhibited a excessive Hosmer-Lemeshow goodness-for-fit and good calibration (P > 0.05). The evaluation, together with the realm beneath the receiver working attribute curve, the online reclassification index, the built-in discrimination enchancment, and medical use, confirmed that our prediction mannequin was extra correct than the Framingham danger mannequin in predicting stroke danger in RA sufferers. In conclusion, the nomogram can be utilized for individualized preoperative prediction of stroke danger in RA sufferers.
Anti-inflammatory and Hepatoprotective Results of Quercetin in an Experimental Mannequin of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune illness characterised by irritation within the joints. Though methotrexate (MX) is the first-line therapy, negative effects are frequent. This research aimed to analyze the results of quercetin (QT) and/or MX on irritation and systemic toxicity in a rat mannequin of RA. Male Wistar rats had been divided into management (C), RA, QT, MX, and QT + MX teams (n=6). The RA induction consisted of three intra-articular injections of methylated bovine serum albumin (1×/week) within the temporomandibular joint (TMJ). QT (25 mg/kg) and/or MX (0.75 mg) administration occurred by oral gavage every day.
We carried out mechanical hyperalgesia in TMJ, leukocyte recruitment in synovial fluid, histopathology, and immunohistochemistry (TNF-α, IL-17, and IL-10) in synovial membrane and toxicity parameters. The RA confirmed a discount within the nociceptive threshold (p<0.001), improve in leukocyte recruitment in synovial fluid (p<0.001), intense inflammatory infiltrate (p<0.001), and intense immunoexpression of TNF-α, IL-17, and IL-10 within the synovial membrane (p<0.001) in comparison with C (p<0.001). QT and/or MX remedy diminished inflammatory parameters (p<0.001).
Nevertheless, downregulation of IL-10 was noticed solely within the teams that acquired MX (p<0.001). Leukocytosis was seen in RA (p<0.05), however QT and/or MX reversed it (p<0.05). MX was related to pathological modifications within the liver and better ranges of transaminases when in comparison with the opposite teams (p<0.05). QT co-administered with MX reversed this hepatotoxicity (p<0.05). There have been no alterations within the kidney between the teams (p>0.05). QT has potential to assist MX remedy, displaying anti-inflammatory and hepatoprotective results on this mannequin.
Metabolically engineered stem cell-derived exosomes to manage macrophage heterogeneity in rheumatoid arthritis
Regardless of the exceptional advances in therapeutics for rheumatoid arthritis (RA), a lot of sufferers nonetheless lack efficient countermeasures. Lately, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic technique for RA. Right here, we report metabolically engineered exosomes which were surface-modified for the focused reprogramming of macrophages. Certified exosomes had been readily harvested from metabolically engineered stem cells by tangential circulate filtration at a excessive yield whereas sustaining their innate immunomodulatory elements.
When systemically administered into mice with collagen-induced arthritis, these exosomes successfully accrued within the infected joints, inducing a cascade of anti-inflammatory occasions through macrophage phenotype regulation. The extent of therapeutic efficacy obtained with naked exosomes was achievable with the engineered exosomes of 10 instances much less dose. On the premise of the boosted nature to reprogram the synovial microenvironment, the engineered exosomes show appreciable potential to be developed as a next-generation drug for RA.
BAFF predicts immunogenicity in older sufferers with rheumatoid arthritis handled with TNF inhibitors
Immunogenicity associated to therapy with TNF inhibitors (TNFi) is among the causes for the decreased attainment of medical response in sufferers with rheumatoid arthritis (RA). The B-cell activating issue (BAFF) could also be enjoying a task within the growth of immunogenicity. The target of this research was to analyse the affiliation of baseline focus of serum B-cell activating issue (BAFF) with immunogenicity after 6 months of TNFi therapy.
A complete of 127 sufferers with RA beginning a TNFi (infliximab, adalimumab, certolizumab pegol or golimumab) had been followed-up for six months. Serum samples had been obtained at baseline and at 6 months and anti-drug antibody (ADA) and BAFF concentrations had been measured. Logistic regression fashions had been employed with the intention to analyse the affiliation between BAFF concentrations and immunogenicity. Receiver working attribute evaluation was carried out to find out the BAFF concentrations with a higher probability of displaying immunogenicity affiliation. At 6 months, 31 sufferers (24%) developed ADA.
 GFP antibody |
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10R-3103 |
Fitzgerald |
100 ug |
EUR 488.4 |
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Description: Mouse monoclonal GFP antibody |
GFP antibody |
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10R-3105 |
Fitzgerald |
100 ug |
EUR 2374.8 |
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Description: Mouse monoclonal FABP7 antibody |
GFP antibody |
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10R-6752 |
Fitzgerald |
100 ug |
EUR 859.2 |
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Description: Mouse monoclonal GFP antibody |
GFP antibody |
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10R-8049 |
Fitzgerald |
100 ug |
EUR 434 |
|
|
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Description: Mouse monoclonal GFP antibody |
GFP antibody |
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20R-2897 |
Fitzgerald |
100 ul |
EUR 471.6 |
|
Description: Rabbit polyclonal GFP antibody |
GFP antibody |
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20R-GR011 |
Fitzgerald |
200 ug |
EUR 488 |
|
|
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Description: Rabbit polyclonal GFP antibody |
GFP antibody |
|
20R-1769 |
Fitzgerald |
100 ug |
EUR 807.6 |
|
Description: Rabbit polyclonal GFP antibody |
 GFP Antibody |
|
48671 |
SAB |
100ul |
EUR 499 |
GFP Antibody |
|
48671-100ul |
SAB |
100ul |
EUR 399.6 |
GFP Antibody |
|
48671-50ul |
SAB |
50ul |
EUR 286.8 |
GFP Antibody |
|
48704 |
SAB |
100ul |
EUR 499 |
GFP Antibody |
|
48704-100ul |
SAB |
100ul |
EUR 399.6 |
GFP Antibody |
|
48704-50ul |
SAB |
50ul |
EUR 286.8 |
GFP Antibody |
|
48705 |
SAB |
100ul |
EUR 499 |
GFP Antibody |
|
48705-100ul |
SAB |
100ul |
EUR 399.6 |
GFP Antibody |
|
48705-50ul |
SAB |
50ul |
EUR 286.8 |
GFP Antibody |
|
48776 |
SAB |
100ul |
EUR 499 |
GFP Antibody |
|
48776-100ul |
SAB |
100ul |
EUR 399.6 |
GFP Antibody |
|
48776-50ul |
SAB |
50ul |
EUR 286.8 |
GFP Antibody |
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35538 |
SAB |
100ul |
EUR 319 |
GFP Antibody |
|
35538-100ul |
SAB |
100ul |
EUR 302.4 |
GFP Antibody |
|
3999-100 |
Biovision |
each |
EUR 424.8 |
GFP Antibody |
|
3999-30T |
Biovision |
each |
EUR 175.2 |
GFP Antibody |
|
abx332839-100ul |
Abbexa |
100 ul |
EUR 510 |
|
|
GFP Antibody |
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E035538 |
EnoGene |
100μg/100μl |
EUR 255 |
|
Description: Available in various conjugation types. |
GFP Antibody |
|
E10-20144 |
EnoGene |
100μg/100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP Antibody |
|
E8M1004-8a |
EnoGene |
100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP Antibody |
|
E301172 |
EnoGene |
100ug/200ul |
EUR 275 |
|
Description: Available in various conjugation types. |
GFP Antibody |
|
E301173 |
EnoGene |
100ug/200ul |
EUR 275 |
|
Description: Available in various conjugation types. |
GFP antibody |
|
70R-12242 |
Fitzgerald |
100 ug |
EUR 413 |
|
|
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Description: Rabbit polyclonal GFP antibody |
GFP antibody |
|
70R-10652 |
Fitzgerald |
400 ul |
EUR 791 |
|
|
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Description: Affinity purified Chicken polyclonal GFP antibody |
GFP antibody |
|
70R-GG001 |
Fitzgerald |
1 mg |
EUR 930 |
|
|
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Description: Affinity purified Goat polyclonal GFP antibody |
GFP Antibody |
|
1-CSB-PA557657 |
Cusabio |
-
Ask for price
-
Ask for price
|
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|
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Description: A polyclonal antibody against GFP. Recognizes GFP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:10000, WB:1:1000-1:10000 |
GFP Antibody |
|
F53773-0.1ML |
NSJ Bioreagents |
0.1 ml |
EUR 330.65 |
|
|
|
Description: Green fluorescent protein (GFP), originally isolated from the jellyfish Aequorea victoria, is one of the best visual reporters for monitoring gene expression in vivo and in situ. GFP is a also convenient marker for use in flow cytometry because it eliminates the need to incubate with asecondary reagent (such as dyes or antibodies) for detection. |
GFP Antibody |
|
T508-100ul |
SAB |
100ul |
EUR 302.4 |
GFP Antibody |
|
T508-50ul |
SAB |
50ul |
EUR 224.4 |
GFP Antibody |
|
abx332839-100g |
Abbexa |
100 µg |
Ask for price |
GFP Antibody |
|
abx332839-20g |
Abbexa |
20 µg |
EUR 362.5 |
GFP Antibody |
|
abx332839-50g |
Abbexa |
50 µg |
Ask for price |
GFP Antibody |
|
MBS7123029-005mL |
MyBiosource |
0.05mL |
EUR 190 |
GFP Antibody |
|
MBS7123029-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1205 |
GFP Antibody |
|
MBS9414561-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1230 |
GFP Antibody |
|
MBS9410457-005mL |
MyBiosource |
0.05mL |
EUR 245 |
GFP Antibody |
|
MBS9410457-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1230 |
GFP Antibody |
|
MBS8584801-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
GFP Antibody |
|
MBS8584801-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
GFP Antibody |
|
MBS8584801-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
GFP Antibody |
|
MBS8584801-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
GFP antibody |
|
MBS831131-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
GFP antibody |
|
MBS830408-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1520 |
GFP Antibody |
|
MBS850015-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
GFP Antibody |
|
MBS850015-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
GFP Antibody |
|
MBS850015-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
GFP Antibody |
|
MBS850015-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
GFP Antibody |
|
MBS8526924-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
GFP Antibody |
|
MBS8526924-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
GFP Antibody |
|
MBS8526924-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
GFP Antibody |
|
MBS8526924-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
GFP Antibody |
|
MBS8526925-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
GFP Antibody |
|
MBS8526925-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
GFP Antibody |
|
MBS8526925-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
GFP Antibody |
|
MBS8526925-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
GFP antibody |
|
MBS200147-005mL |
MyBiosource |
0.05mL |
EUR 260 |
GFP antibody |
|
MBS200147-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1300 |
GFP antibody |
|
MBS532871-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
GFP antibody |
|
MBS531060-5x1mg |
MyBiosource |
5x1mg |
EUR 9410 |
GFP Antibody |
|
MBS5311570-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2435 |
GFP Antibody |
|
MBS5400410-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1855 |
GFP antibody |
|
MBS533341-5x01mL |
MyBiosource |
5x0.1mL |
EUR 3015 |
GFP antibody |
|
MBS533842-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
GFP antibody |
|
MBS534285-5x1mg |
MyBiosource |
5x1mg |
EUR 8180 |
GFP antibody |
|
MBS534482-5x02mg |
MyBiosource |
5x0.2mg |
EUR 2730 |
GFP Antibody |
|
MBS9435512-005mL |
MyBiosource |
0.05mL |
EUR 325 |
GFP Antibody |
|
MBS9435512-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
GFP Antibody |
|
MBS9435540-005mL |
MyBiosource |
0.05mL |
EUR 325 |
GFP Antibody |
|
MBS9435540-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
GFP Antibody |
|
MBS9435541-005mL |
MyBiosource |
0.05mL |
EUR 325 |
GFP Antibody |
|
MBS9435541-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
GFP Antibody |
|
MBS9435607-005mL |
MyBiosource |
0.05mL |
EUR 325 |
GFP Antibody |
|
MBS9435607-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1810 |
GFP Antibody |
|
PHY5020 |
PhytoAB |
150 μg |
EUR 318 |
 Anti- GFP Antibody |
|
102-PA84 |
ReliaTech |
50 µg |
EUR 89.25 |
|
Description: Green Fluorescent Protein (GFP) has quickly become a powerful research tool for assessing gene expression and subcellular protein distribution in fixed or living cells. GFP is excited by and brightly fluoresces when exposed to UV or blue light. This feature makes it ideal as a marker for use in fluorescence microscopy, cytometry, tagging fusion proteins, and assaying transcriptional regulation from gene promoters in vivo. Numerous GFP variants with enhanced and shifted emission spectra (blue, green, and yellow) have been developed through amino acid substitutions at specific residues. The antibody was made against GFP from the jellyfish Aequorea Victoria using the whole native protein as an antigen. |
 Antibody) GFP (FL) Antibody |
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48297 |
SAB |
100ul |
EUR 429 |
GFP (FL) Antibody |
|
48297-100ul |
SAB |
100ul |
EUR 399.6 |
GFP (FL) Antibody |
|
48297-50ul |
SAB |
50ul |
EUR 286.8 |
 Antibody) GFP (FL) Antibody |
|
MBS9435160-005mL |
MyBiosource |
0.05mL |
EUR 325 |
GFP (FL) Antibody |
|
MBS9435160-01mL |
MyBiosource |
0.1mL |
EUR 445 |
GFP (FL) Antibody |
|
MBS9435160-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1860 |
) GFP antibody (HRP) |
|
60R-GG002hrp |
Fitzgerald |
1 mg |
EUR 884 |
|
|
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Description: Goat polyclonal GFP antibody (HRP) conjugated |
GFP antibody (HRP) |
|
61R-G103aHRP |
Fitzgerald |
1 mg |
EUR 1238 |
|
|
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Description: Mouse monoclonal GFP antibody (HRP) |
) GFP Antibody (YFP) |
|
F52058-0.05ML |
NSJ Bioreagents |
0.05 ml |
EUR 140.25 |
|
|
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Description: Green fluorescent protein is one of the best visual reporters for monitoring gene expression in vivo and in situ. It is a also convenient marker for use in flow cytometry because it eliminates the need to incubate with a secondary reagent (such as dyes or antibodies) for detection. However, anti-GFP antibody is also widely used for co-immunipreciapitation, co-localization or western blotting for the confirmation of specificity when a GFP fusion protein is expressed in cells. NSJBio's anti-GFP antibody provides a simple solution to detect the expression of a GFP-tagged protein in cells. Because of its ability to spontaneously generate its own fluorophore, the green fluorescent protein from the jellyfish Aequorea victoria is used extensively as a fluorescent marker in molecular and cell biology. The yellow fluorescent proteins (YFPs) have the longest wavelength emissions of all GFP variants examined to date. This shift in the spectrum is the result of a T203Y substitution (single-letter amino acid code), a mutation rationally designed on the basis of the X-ray structure of GFP S65T. NSJBio's anti-GFP antibody can detect both GFP and YFP but not BFP (Blue fluorescent protein) by western blotting. |
 GFP Antibody / YFP |
|
F52058-0.2ML |
NSJ Bioreagents |
0.2 ml |
EUR 330.65 |
|
|
|
Description: Green fluorescent protein is one of the best visual reporters for monitoring gene expression in vivo and in situ. It is a also convenient marker for use in flow cytometry because it eliminates the need to incubate with a secondary reagent (such as dyes or antibodies) for detection. However, anti-GFP antibody is also widely used for co-immunipreciapitation, co-localization or western blotting for the confirmation of specificity when a GFP fusion protein is expressed in cells. NSJBio's anti-GFP antibody provides a simple solution to detect the expression of a GFP-tagged protein in cells. Because of its ability to spontaneously generate its own fluorophore, the green fluorescent protein from the jellyfish Aequorea victoria is used extensively as a fluorescent marker in molecular and cell biology. The yellow fluorescent proteins (YFPs) have the longest wavelength emissions of all GFP variants examined to date. This shift in the spectrum is the result of a T203Y substitution (single-letter amino acid code), a mutation rationally designed on the basis of the X-ray structure of GFP S65T. NSJBio's anti-GFP antibody can detect both GFP and YFP but not BFP (Blue fluorescent protein) by western blotting. |
GFP antibody (HRP) |
|
MBS530242-1mg |
MyBiosource |
1mg |
EUR 2150 |
GFP antibody (HRP) |
|
MBS530242-5x1mg |
MyBiosource |
5x1mg |
EUR 9530 |
GFP antibody (HRP) |
|
MBS534313-1mg |
MyBiosource |
1mg |
EUR 1670 |
GFP antibody (HRP) |
|
MBS534313-5x1mg |
MyBiosource |
5x1mg |
EUR 7370 |
 GFP Antibody FITC |
|
MBS5400412-01mg |
MyBiosource |
0.1mg |
EUR 560 |
GFP Antibody FITC |
|
MBS5400412-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2380 |
) GFP antibody (biotin) |
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60R-GG001bt |
Fitzgerald |
1 mg |
EUR 884 |
|
|
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Description: Goat polyclonal GFP antibody (biotin) conjugated |
 GFP Antibody BIOTIN |
|
MBS5400411-01mg |
MyBiosource |
0.1mg |
EUR 560 |
GFP Antibody BIOTIN |
|
MBS5400411-5x01mg |
MyBiosource |
5x0.1mg |
EUR 2380 |
GFP antibody (biotin) |
|
MBS534795-1mg |
MyBiosource |
1mg |
EUR 1970 |
GFP antibody (biotin) |
|
MBS534795-5x1mg |
MyBiosource |
5x1mg |
EUR 8705 |
 GFP Antibody, 100 uL |
|
P601-100 |
101Bio |
- |
Ask for price |
 GFP Antibody, 10 uL |
|
P601-10 |
101Bio |
- |
Ask for price |
 GFP Tag antibody |
|
10R-10269 |
Fitzgerald |
100 ug |
EUR 229 |
|
|
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Description: Mouse monoclonal GFP Tag antibody |
 GFP Tag Antibody |
|
E559003-15-PU |
EnoGene |
100ug |
EUR 295 |
|
Description: Available in various conjugation types. |
GFP Tag Antibody |
|
MBS855592-01mg |
MyBiosource |
0.1mg |
EUR 370 |
GFP Tag Antibody |
|
MBS855592-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
GFP Tag Antibody |
|
MBS855592-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
GFP Tag Antibody |
|
MBS855592-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
GFP Tag Antibody |
|
MBS855592-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
GFP Tag Antibody |
|
MBS9200313-005mL |
MyBiosource |
0.05mL |
EUR 210 |
GFP Tag Antibody |
|
MBS9200313-02mL |
MyBiosource |
0.2mL |
EUR 430 |
GFP Tag Antibody |
|
MBS9200313-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1910 |
 Antibody) GFP (C19) Antibody |
|
MBS440058-02mg |
MyBiosource |
0.2mg |
EUR 285 |
GFP (C19) Antibody |
|
MBS440058-5x02mg |
MyBiosource |
5x0.2mg |
EUR 1185 |
 Antibody) GFP (FL3) Antibody |
|
MBS440077-01mg |
MyBiosource |
0.1mg |
EUR 350 |
GFP (FL3) Antibody |
|
MBS440077-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1480 |
 GFP tag antibody |
|
MBS355040-01mg |
MyBiosource |
0.1mg |
EUR 290 |
GFP tag antibody |
|
MBS355040-5x01mg |
MyBiosource |
5x0.1mg |
EUR 995 |
) Affinity Purified Rabbit anti-GFP (GFP Antibody) |
|
MBS560494-01mg |
MyBiosource |
0.1mg |
EUR 285 |
Affinity Purified Rabbit anti-GFP (GFP Antibody) |
|
MBS560494-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1120 |
 GFP-Tag Antibody |
|
20-abx242884 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
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GFP-Tag Antibody |
|
20-abx330286 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
 GFP-tag Antibody |
|
E38PA9021 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP-tag Antibody |
|
E38PA9022 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP-tag Antibody |
|
E38PA9023 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP-tag Antibody |
|
E38PA9056 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
GFP-Tag Antibody |
|
1-CSB-PA000342 |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
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Description: A polyclonal antibody against GFP-Tag. Recognizes GFP-Tag from . This antibody is Unconjugated. Tested in the following application: WB;WB:1:5000 |
GFP-Tag Antibody |
|
abx242884-96tests |
Abbexa |
96 tests |
EUR 200 |
A major interplay between the age and baseline BAFF focus was discovered for the event of ADA (Wald chi-square worth = 5.30; p = 0.02); subsequently, subsequent outcomes had been stratified based on imply age (≤ / > 55 years). Baseline serum BAFF focus was independently related to ADA growth solely in sufferers over 55 years (OR = 1.51; 95% CI 1.03-2.21). Baseline serum BAFF ≥ 1034 pg/mL predicted the presence of ADA at 6 months (AUC = 0.81; 95% confidence interval (CI) 0.69-0.93; p = 0.001; optimistic probability ratio = 3.7). In conclusion, our outcomes recommend that the affiliation of BAFF focus and immunogenicity is determined by the affected person’s age. Baseline serum BAFF focus predicts the presence of ADA inside 6 months of TNFi remedy in older sufferers with RA.
