Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature

Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature
June 25, 2021 0 Comments

A 64-year-old male introduced with a 6-month historical past of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints of the fingers, wrists, and ankles. Related signs included vomiting, progressive fatigue, and weight reduction. Laboratory outcomes confirmed microcytic anemia, leukocytosis, thrombocytosis, elevated C-reactive protein and erythrocyte sedimentation price, and rheumatoid issue (RF) and anti-cyclic citrullinated protein (ACPA) antibody positivity.
Joints radiographs have been regular, with out erosions. Higher endoscopy and gastric endoscopic ultrasonography confirmed a gastric adenocarcinoma with lymphatic involvement. Intraoperatively, peritoneal carcinomatosis was documented, and the affected person began palliative chemotherapy. A paraneoplastic seropositive arthritis was assumed, and remedy with low-dose prednisolone and hydroxychloroquine was began. Arthritis remission was achieved and sustained as much as 18 months of follow-up, though gastric most cancers development was documented.
We describe a novel phenotype of paraneoplastic arthritis (PA) presenting as a seropositive (RF and ACPA positivity) rheumatoid arthritis (RA) with a very good response to each low dose corticosteroids and hydroxychloroquine remedy. We additionally assessment the literature of PA, largely the RA-like sample, and the affiliation between PA and ACPA positivity. This case highlights the significance of contemplating underlying most cancers in aged male sufferers, presenting with polyarthritis and systemic signs, even in these with ACPA-positive RA-like arthritis.

Pharmacokinetics-Based mostly Chronoefficacy of Semen Strychni and Tripterygium Glycoside Pill Towards Rheumatoid Arthritis

Rheumatoid arthritis is a systemic autoimmune illness characterised by synovial irritation and bone destruction. Figuring out medicine with time-varying efficacy and toxicity, and elucidating the mechanisms would assist to enhance remedy efficacy and scale back antagonistic results. Right here, we aimed to find out the chronoefficacy of semen strychni (SS) and tripterygium glycoside pill (TGT) in opposition to rheumatoid arthritis in mice, and to analyze a possible position of circadian pharmacokinetics in producing chronoefficacy.
SS extract and TGT suspension have been ready with ultrasonication. Results of SS and TGT on collagen-induced arthritis (CIA) have been evaluated by measuring TNF-α and IL-6 ranges. SS dosed at ZT18 was simpler in defending in opposition to CIA than drug dosed at ZT6 (i.e., decrease ranges of key inflammatory elements at ZT18 than at ZT6). This was accompanied by increased systemic publicity ranges of strychnine and brucine (two foremost putative energetic components of SS) in ZT18-treated than in ZT6-treated CIA mice. TGT dosing at ZT2 confirmed a greater efficacy in opposition to CIA as in comparison with herb doing at ZT14. Persistently, ZT2 dosing generated a better publicity of triptolide (a foremost putative energetic ingredient of TGT) as in comparison with ZT14 dosing in CIA mice.
 Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature
Furthermore, strychnine, brucine, and triptolide considerably inhibited the proliferation of fibroblast-like synoviocytes, and diminished the manufacturing of TNF-α and IL-6 and the mRNAs of TNF-α, IL-6, COX-2, and iNOS, suggesting that they possessed an anti-arthritis exercise. In conclusion, SS and TGT show chronoefficacy in opposition to rheumatoid arthritis in mice, that’s attributed to circadian pharmacokinetics of foremost energetic components. Our findings have implications for enhancing remedy outcomes of SS and TGT by way of timed supply.

In direction of Prevention of Autoimmune Ailments: The Instance of Rheumatoid Arthritis

Prevention is the last word intention for clinicians and scientists involved with extreme illnesses, like many immune-mediated circumstances. Right here, we describe current progress within the understanding of aetiology and molecular pathogenesis of rheumatoid arthritis (RA), which make this illness a possible prototype for prevention which will embrace each public well being measures and focused and personalised approaches that we name “personalised prevention”
. Important parts of this data are (i) higher understanding of the dynamics of the RA-associated autoimmunity which will start a few years earlier than onset of joint irritation; (ii) insights into how this immunity could also be triggered at mucosal surfaces after distinct environmental challenges; (iii) higher understanding of which options of the pre-existing immunity could trigger signs that precede joint irritation and predict a excessive threat for imminent arthritis growth; and (iv) how molecular occasions occurring earlier than onset of irritation is likely to be focused by current or future therapies, finally by particular concentrating on of Main histocompatibility advanced (MHC) class II restricted and RA-specific immunity.
Our foremost conclusion is that research and interventions within the section of autoimmunity previous RA supply new alternatives to stop the illness and thereby additionally perceive the molecular pathogenesis of its totally different variants. This text is protected by copyright. All rights reserved.

Present and Rising DMARDs for the Therapy of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is probably the most prevalent type of inflammatory arthritis. It’s a profoundly severe and extreme illness that if it goes untreated might have extreme penalties to the joints and well being of the affected person who carries this analysis. The remedy of RA has dramatically modified because the yr 2000, with the invention of the TNFis, then different biologics, and at last the JAKi. All these new drugs with or with out methotrexate together, tight management and deal with to focus on have produced a revolution within the end result of this illness.

TNN Conjugated Antibody

C37267 100ul
EUR 397

TNN siRNA

20-abx937676
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

TNN siRNA

20-abx937677
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

Tenascin-N (TNN) Antibody

abx027503-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Tenascin-N (TNN) Antibody

abx027503-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Tenascin-N (TNN) Antibody

20-abx213586
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Tenascin-N (TNN) Antibody

20-abx213587
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

TNN Antibody, HRP conjugated

1-CSB-PA892498LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNN. Recognizes TNN from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

TNN Antibody, FITC conjugated

1-CSB-PA892498LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNN. Recognizes TNN from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TNN Antibody, Biotin conjugated

1-CSB-PA892498LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNN. Recognizes TNN from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Mouse TNN shRNA Plasmid

20-abx983554
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Human TNN ELISA Kit

ELA-E6753h 96 Tests
EUR 824

TNN ELISA KIT|Human

EF006402 96 Tests
EUR 689

Human TNN shRNA Plasmid

20-abx961862
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Polyclonal TNN antibody - N-terminal region

AMM08262G 0.05mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNN - N-terminal region. This antibody is tested and proven to work in the following applications:

TNN ORF Vector (Human) (pORF)

ORF034128 1.0 ug DNA
EUR 405

Tnn ORF Vector (Mouse) (pORF)

ORF060119 1.0 ug DNA
EUR 1572

Tnn ORF Vector (Rat) (pORF)

ORF078047 1.0 ug DNA
EUR 2080

TNN ELISA Kit (Mouse) (OKEH05060)

OKEH05060 96 Wells
EUR 779
Description: Description of target: Isoform 2 inhibits neurite outgrowth and cell migration in hippocampal explants while isoform 1 does not have this affect.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 40.8 pg/mL

Mouse Tenascin-N (TNN) ELISA Kit

abx520606-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Mouse Tnn/ Tenascin-N ELISA Kit

E1507Mo 1 Kit
EUR 632

Human TNN/ Tenascin-N ELISA Kit

E2557Hu 1 Kit
EUR 605

Human TNN(Tenascin-N) ELISA Kit

EH2345 96T
EUR 567.6
  • Detection range: 0.312-20 ng/ml
  • Uniprot ID: Q9UQP3
  • Alias: TNN
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human Tenascin- N, TNN ELISA KIT

ELI-07573h 96 Tests
EUR 824

Mouse Tenascin- N, Tnn ELISA KIT

ELI-07574m 96 Tests
EUR 865

Human Tenascin-N (TNN) ELISA Kit

abx251701-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

TNN sgRNA CRISPR Lentivector set (Human)

K2419101 3 x 1.0 ug
EUR 339

Human Tenascin-N(TNN) ELISA kit

CSB-EL024008HU-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Tenascin-N (TNN) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Tenascin-N(TNN) ELISA kit

1-CSB-EL024008HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Tenascin-N(TNN) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Tnn sgRNA CRISPR Lentivector set (Mouse)

K3893901 3 x 1.0 ug
EUR 339

Tnn sgRNA CRISPR Lentivector set (Rat)

K6576501 3 x 1.0 ug
EUR 339

Human Tenascin N(TNN)ELISA Kit

QY-E03057 96T
EUR 361

TNN sgRNA CRISPR Lentivector (Human) (Target 1)

K2419102 1.0 ug DNA
EUR 154

TNN sgRNA CRISPR Lentivector (Human) (Target 2)

K2419103 1.0 ug DNA
EUR 154

TNN sgRNA CRISPR Lentivector (Human) (Target 3)

K2419104 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3893902 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3893903 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3893904 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Rat) (Target 1)

K6576502 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Rat) (Target 2)

K6576503 1.0 ug DNA
EUR 154

Tnn sgRNA CRISPR Lentivector (Rat) (Target 3)

K6576504 1.0 ug DNA
EUR 154

ELISA kit for Mouse Tenascin-N (TNN)

KTE70103-48T 48T
EUR 332
  • TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Dysplastic Nevus Syndrome. Among its related pathways are ECM proteoglycans and ECM-receptor interaction. GO annotations related to this gene include identical protein bi
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Tenascin-N (TNN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Tenascin-N (TNN)

KTE70103-5platesof96wells 5 plates of 96 wells
EUR 2115
  • TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Dysplastic Nevus Syndrome. Among its related pathways are ECM proteoglycans and ECM-receptor interaction. GO annotations related to this gene include identical protein bi
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Tenascin-N (TNN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Tenascin-N (TNN)

KTE70103-96T 96T
EUR 539
  • TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Dysplastic Nevus Syndrome. Among its related pathways are ECM proteoglycans and ECM-receptor interaction. GO annotations related to this gene include identical protein bi
  • Show more
Description: Quantitative sandwich ELISA for measuring Mouse Tenascin-N (TNN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

TNN Protein Vector (Rat) (pPB-C-His)

PV312186 500 ng
EUR 2632

TNN Protein Vector (Rat) (pPB-N-His)

PV312187 500 ng
EUR 2632

TNN Protein Vector (Rat) (pPM-C-HA)

PV312188 500 ng
EUR 2632

TNN Protein Vector (Rat) (pPM-C-His)

PV312189 500 ng
EUR 2632

TNN Protein Vector (Human) (pPB-C-His)

PV136510 500 ng
EUR 811

TNN Protein Vector (Human) (pPB-N-His)

PV136511 500 ng
EUR 811

TNN Protein Vector (Human) (pPM-C-HA)

PV136512 500 ng
EUR 811

TNN Protein Vector (Human) (pPM-C-His)

PV136513 500 ng
EUR 811

TNN Protein Vector (Mouse) (pPB-C-His)

PV240474 500 ng
EUR 2629

TNN Protein Vector (Mouse) (pPB-N-His)

PV240475 500 ng
EUR 2629

TNN Protein Vector (Mouse) (pPM-C-HA)

PV240476 500 ng
EUR 2629

TNN Protein Vector (Mouse) (pPM-C-His)

PV240477 500 ng
EUR 2629

Tnn 3'UTR GFP Stable Cell Line

TU170915 1.0 ml Ask for price

TNN 3'UTR GFP Stable Cell Line

TU076053 1.0 ml
EUR 1394

Tnn 3'UTR Luciferase Stable Cell Line

TU120915 1.0 ml Ask for price

TNN 3'UTR Luciferase Stable Cell Line

TU026053 1.0 ml
EUR 1394

Tnn 3'UTR Luciferase Stable Cell Line

TU222267 1.0 ml Ask for price

Tnn 3'UTR GFP Stable Cell Line

TU272267 1.0 ml Ask for price

TNN ELISA Kit (Human) : 96 Wells (OKEH01796)

OKEH01796 96 Wells
EUR 779
Description: Description of target: ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.1 ng/mL

Tnn ELISA Kit| Mouse Tenascin-N ELISA Kit

EF016364 96 Tests
EUR 689

TNN Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV650575 1.0 ug DNA
EUR 2457

TNN Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV650579 1.0 ug DNA
EUR 2457

TNN Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV650580 1.0 ug DNA
EUR 2457

TNN sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K2419105 3 x 1.0 ug
EUR 376

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3893905 3 x 1.0 ug
EUR 376

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6576505 3 x 1.0 ug
EUR 376

TNN sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K2419106 1.0 ug DNA
EUR 167

TNN sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K2419107 1.0 ug DNA
EUR 167

TNN sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K2419108 1.0 ug DNA
EUR 167

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3893906 1.0 ug DNA
EUR 167

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3893907 1.0 ug DNA
EUR 167

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3893908 1.0 ug DNA
EUR 167

TNN Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV650576 1.0 ug DNA
EUR 2457

TNN Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV650577 1.0 ug DNA
EUR 2515

TNN Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV650578 1.0 ug DNA
EUR 2515

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6576506 1.0 ug DNA
EUR 167

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6576507 1.0 ug DNA
EUR 167

Tnn sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6576508 1.0 ug DNA
EUR 167

H2B Antibody Antibody

AF4659 200ul
EUR 376
Description: H2B Antibody Antibody detects endogenous levels of H2B.

CD11b Antibody Antibody

ABD2911 100 ug
EUR 438

anti- Antibody^Polyclonal antibody control antibody

LSMab09882 100 ug
EUR 438

Ly1 Antibody Reactive (LYAR) Antibody

20-abx123734
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx036399-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx008109
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

20-abx004855
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx014333
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx324434
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319900
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319901
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319905
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319913
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx311665
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx234901-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx230204-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Anti-Anti-SEPT2 Antibody antibody

STJ28365 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT6 antibody antibody

STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Anti-Anti-SEPT2 Antibody antibody

STJ25475 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-SEPT8 Antibody antibody

STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT9 Antibody antibody

STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

Anti-Anti-SEPT11 Antibody antibody

STJ111530 100 µl
EUR 277

Anti-Anti-SEPT4 Antibody antibody

STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Anti-Anti-MARCH9 Antibody antibody

STJ112609 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ113941 100 µl
EUR 277
We reviewed and summarized the remedy choices, and probably the most vital papers for every one in all these new medicine. The reader might have a full image with all of the references of the current publications. We additionally up to date the biosimilar state of affairs in RA, in addition to the brand new medicine that will likely be coming to the market within the subsequent 5 years.

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